On the Wind River Indian Reservation in Wyoming, Cory Lambert (Jeremy Renner) is a tracker and hunter of threatening wildlife on the reservation, protecting the people from dangerous animals. Cory finds the corpse of a teenage girl when patrolling the reservation. Young FBI agent Jane Banner (Elizabeth Olsen) is sent in to investigate. New, inexperienced, and idealistic, Jane is quickly in over her head trying to solve the murder while adjusting to the culture shift on an Indian reservation. Cory knows the land and the people of Wind River, and Jane enlists his help.